Alzheimers treatments - Niacinamide, magnesium threonate, tocotrienols, melatonin, curcumin as potential cures, per scientific studies. Alzheimer's checklist. Study, research, other info for Alzheimer's help. Is it really Alzheimers?
Note that much of the Alzheimer's info below involves Alzheimer's supplements. That does not minimize the miraculous results some medical practitioners are having with these often amazing Alzheimers nutrients.
As an Alzheimers treatment, large doses of niacinamide, also known as nicotinamide, a form of vitamin B3, "cured" Alzheimers disease in mice, reports health researcher/reporter Dr. David Williams. (Note: Niacinamide is NOT the same as niacin. Do not confuse the two.)
"Rarely do you hear researchers using the word 'cured,' but that's exactly what happened," says Dr. Williams. "At the end of the Alzheimer's research study, the diseased mice that were treated with niacinamide performed just as well in memory tests as healthy mice. The niacinamide not only protected their brains from further memory loss, it also restored lost memory function."
Before reading any further,
see our medical disclaimer.
(Note: Alzheimer's is frequently misspelled alzhiemers, alzhimers, alzeimers, altzheimers, alheimers, alsheimers, alzimers, alzhiemer's and alziemers.)
The study of this treatment for Alzheimer's disease, headed by Dr. Kim Green at the University of California at Irvine, involved four months of Alzheimers treatment with the human dose equivalent of 2000 to 3000 milligrams of niacinamide. "Cognitively, they were cured," said Dr. Green. "The vitamin completely prevented cognitive decline associated with the disease, bringing them back to the level they'd be at if they didn't have the pathology." Niacinamide also improved memory in mice without Alzheimer's. Here's the UC Irvine press release on the results of the study, which refers to "nicotinamide," another name for niacinamide: "Vitamin B3 reduces Alzheimer’s symptoms, lesions."
The late Dr. William Kaufman did extensive research on niacinamide in the 1930s. Dr. Kaufman found that niacinamide moves in and out of the body quickly, so that smaller doses throughout the day are most effective, with 250 milligrams being the most the body could utilize at one time.
Dr. Kaufman and his wife took 250 milligrams of niacinamide every three waking hours (six doses) for at least 55 years, believing, as a result of his studies, that it helps prevent many of the physical and mental problems associated with aging, including arthritis, fatigue, muscle strength, loss of balance, depression, and cancer.
Alzheimer's treatments should be safe. Niacinamide has been widely used for a variety of purposes for more than 60 years, and its safety is well known, says Jonathan Wright, M.D. In one of Dr. Kaufman's books, Kaufman described symptoms of niacinamide deficiency:
Dr. Kaufman found that these symptoms and more went away or improved a lot with the use of niacinamide, says Dr. Wright. Arthritis symptoms also improve or disappear with niacinamide, says Dr. Wright, but it's not a cure; the arthritis symptoms return if patients stop taking it.
Be certain what you're taking is NOT niacin, which can have many more side effects, particularly at high doses. Use niacinamide, not niacin, says Dr. Wright.
Based on Dr. Kaufman's work, Dr. Williams estimates that Alzheimer's patients "would achieve the best results if they took 250 mg every 1½ hours (a total of 12 doses)" for Alzheimers treatment. For more info on Dr. Wright's regimen, which is higher doses at less frequent intervals, read his newsletter. This larger-dose, less-frequent regimen can cause side effects in a small number of people. Check with your own doctor.
Keep in mind that this Alzheimer's "cure" only works for mice so far. Given the outstanding results in mice, human trials for Alzheimers treatment are proceeding at UC Irvine and in England. In humans, taking 2000 to 3000 milligrams a day is "totally harmless," says Dr. Williams. The toxic dose would be nearly a pound of niacinamide daily, and there has never been a death reported from niacinamide supplementation.
Dr. Williams says, "I personally utilized Dr. Kaufman's protocols for several years and saw some amazing improvements; however, I saw even better responses after switching to a product without preservatives." One source of preservative-free niacinamide for Alzheimers treatment is Freeda Vitamins, 800-777-3737 or freedavitamins.com.
Note: Niacinamide also works for joint function, Mobility and repair, says Dr. Williams. See his article.
Bottom Line Natural Healing with Dr. Mark Stengler, July 2011, by Mark Stengler, NMD
Alternatives newsletter, February 2009, by Dr. David Williams. J Neurosci 08:28:11500-11510
Nutrition & Healing newsletter, March 2009, by Jonathan Wright, M.D.
Life Extension magazine, April 2009, p. 22
Although magnesium has a long history as a nutrient important for brain function, recent research has confirmed that a special form of it specifically contributes to learning and memory because of its favorable effect on “synaptic plasticity and density.” Synaptic density and plasticity are the structural bases of learning and memory, perfect for an Alzheimers treatment.
A unique supplement, magnesium-L-threonate (MgT), could be an Alzheimers treatment because it rebuilds ruptured synapses and restores degraded neuronal connections seen in Alzheimer’s and other forms of memory loss. Unlike other magnesium supplements, this one significantly raises magnesium levels in the brain. Until the formulation and testing of MgT by scientists at the Massachusetts Institute of Technology (MIT), no widely available kinds of magnesium allowed “rapid absorption and efficient transfer into the central nervous system.”
Tests showed that magnesium-L-threonate improves multiple forms of learning and memory in animals. The tests were done on young and old animals, and the results are so encouraging that human trials are pending.
Following is a list of what researchers discovered during the tests:
In summary, magnesium-L-threonate as an Alzheimers treatment boosts brain magnesium levels better than standard magnesium supplements, producing dramatic increases in synaptic density and plasticity and similar improvements in memory function itself, giving it potential as an Alzheimer’s treatment.
My summary of this subject was taken from a lengthy article in Life Extension magazine, titled "Novel Magnesium Compound Reverses Neurodegeneration," February 2012, p. 33-36. At the end of the article are 42 scientific references.
Life Extension sells magnesium-L-threonate, and it is readily available online, and probably at your health food store as an Alzheimer's treatment.
Al Sears, M.D. has had "great success" in treating patients with Alzheimer's, stroke and dementia with tocotrienols, which are part of the Vitamin E complex. This supplement speeds up brain healing, says Sears, making it appropriate for Alzheimers treatment. Read all about it on the benefits of tocotrienols page.
Turmeric is showing great promise as an Alzheimers treatment. The active ingredient in turmeric is curcumin. This component is believed to be responsible for most of turmeric’s health effects.
One of the most comprehensive summaries of turmeric studies was published by James A. Duke, Phd., in the October, 2007 issue of Alternative & Complementary Therapies, and summarized in the July, 2008, issue of the American Botanical Council publication HerbClip.
Duke found more than 50 studies on turmeric’s effects as an Alzheimers treatment. The reports indicate that extracts of turmeric contain a number of natural agents that block the formation of beta-amyloid, the substance responsible for the plaques that slowly obstruct cerebral function in Alzheimer’s disease. Duke concluded turmeric dramatically outperforms many synthetic drugs in its power to both prevent and treat Alzheimer’s plaques.
As for how it works, an important review in Annals of Indian Academy of Neurology, titled "The effect of curcumin (turmeric) on Alzheimer's disease" covers the subject in overwhelming detail.
The review is long and very technical. I have pulled the following out of it for you, hoping to write it in readable English. The portions in quotes are directly from the review:
The review says, "No apparent side effects have been reported thus far." However, curcumin interacts with some prescription drugs. Also, it should not be used by people with certain medical conditions. Read the study for details; search on side effect. Be sure to check with your doctor before taking it.
There is much more information available online. Just search on:
Alzheimer's tumeric curcumin
This book looks interesting:
How 9 maverick doctors are reversing Alzheimer's
Recent studies report ALC may reverse Alzheimer’s disease symptoms of memory loss and problems with focus. In this study: Acetyl-L-carnitine rescues [Alzheimer's] memory deficits, the drug scopolamine was used to imitate Alzheimer's symptoms, which were partially reversed by ALC.
Extended use of ALC by Alzheimer’s and dementia
patients slowed deterioration of mental functions. Long-term acetyl-L-carnitine treatment in Alzheimer's disease.
ALC comes in capsule or powder form. Both are good, but capsules are easier and faster to take. For the best results, take 1500 mg twice daily in capsule form, says Al Sears, M.D. in Dr. Sears Confidential Cures 12/15.
Phosphatidyl serine plays a vital role in neuron health and healing. Unfortunately, we produce less of this essential brain nutrient as we age. To counter this, you need to supplement to remain sharp.
See this article from Life Extension magazine: Alzheimer's Disease: Targeted Nutritional Strategies, which tells of memory loss reversed with phosphatidyl serine. The article also covers other supplements helpful to Alzheimer's patients.
Dr. Sears recommends a 500 milligram supplement of PS three times daily for 30 days to get started. After that, take 500 mg twice daily, he says.
Studies show that Alzheimer’s and dementia patients have lower than average levels of DHA (docosahexaenoic acid) and also suffer from brain shrinkage.
In one clinical trial, Alzheimer’s patients who took 900 mg of DHA per day experienced near-immediate memory improvement.
Here's another study that highlights the value of DHA for Alzheimer's treatment.
A study on melatonin for Alzheimers treatment included 80 men and women with mild to moderate Alzheimer's disease. Half the participants got two milligrams of prolonged-release melatonin every night for six months. The others got a placebo. Patients who got the melatonin got significantly highter scores on the IADL and MMSE, meaning better cognitive function and also better sleep efficiency.
IADL measures how well patients can take care of themselves. MMSE measures memory and cognition.
Here's an easy-to-read version of the study in the Life Extension magazine newsletter, June 9, 2015:
Please see our page on Parkinson's Disease Treatment for details.
Please see our page on Parkinson's Disease Treatments for details on using this group of supplements for Alzheimer's treatment.
Music may hold promise as an Alzheimers treatment. Alzheimer's patients remember information better when it is sung to them, rather than spoken. See the study: http://bit.ly/1MeA2Dd
Watch an amazing video of a formerly unresponsive man with Alzheimer's/dementia in a nursing home responding to music: http://bit.ly/1LZYo0H
Preliminary lab studies at the Salk Institute find that THC reduces beta amyloid proteins in human brain cells.
Salk Institute scientists have found that tetrahydrocannabinol (THC) and other compounds found in marijuana can promote the cellular removal of amyloid beta, a toxic protein associated with Alzheimer’s disease.
While these exploratory studies were conducted in neurons grown in the laboratory, not in humans they could provide clues to developing new Alzheimers treatments.
Sometimes, although rarely, symptoms of Alzheimer's are actually caused by something else:
This information came from the following source: Dear Doctor K, a syndicated newspaper column by Anthony Komaroff, M.D., 2/22/15.
"Come to Me, all of you who are weary and carry heavy burdens, and I will give you rest." Matthew 11:28.
A number of studies have linked prayer to healing, and although the results have been inconclusive, what could it hurt to talk to the omnipotent creator of the universe? A prayer for healing might go something like this:
"Dear Lord, please hear me now as I pray for your help with (name your problem). I pray you’ll cleanse my body and heal me completely. In Jesus’ name I pray; Amen."
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