Alzheimers Treatment News for patients and caregivers

Alzheimers treatment - Niacinamide, magnesium threonate, tocotrienols, melatonin, curcumin as potential cures, per scientific studies. Alzheimer's checklist. Information, news, study, research, facts for Alzheimer's help. Is it really Alzheimers? 

Niacinamide for Alzheimer's

As an Alzheimers treatment, large doses of niacinamide, also known as nicotinamide, a form of vitamin B3, "cured" Alzheimers disease in mice, reports health researcher/reporter Dr. David Williams. (Note: Niacinamide is NOT the same as niacin. Do not confuse the two.)

"Rarely do you hear researchers using the word 'cured,' but that's exactly what happened," says Dr. Williams. "At the end of the Alzheimer's research study, the diseased mice that were treated with niacinamide performed just as well in memory tests as healthy mice. The niacinamide not only protected their brains from further memory loss, it also restored lost memory function."

Before reading any further,
see our medical disclaimer.

(Note: Alzheimer's is frequently misspelled alzhiemers, alzhimers, alzeimers, altzheimers, alheimers, alsheimers, alzimers, alzhiemer's and alziemers.)

The study of this treatment for Alzheimer's disease, headed by Dr. Kim Green at the University of California at Irvine, involved four months of Alzheimers treatment with the human dose equivalent of 2000 to 3000 milligrams of niacinamide. "Cognitively, they were cured," said Dr. Green. "The vitamin completely prevented cognitive decline associated with the disease, bringing them back to the level they'd be at if they didn't have the pathology." Niacinamide also improved memory in mice without Alzheimer's. Here's the UC Irvine press release on the results of the study, which refers to "nicotinamide," another name for niacinamide: "Vitamin B3 reduces Alzheimer’s symptoms, lesions."

The late Dr. William Kaufman did extensive research on niacinamide in the 1930s. Dr. Kaufman found that niacinamide moves in and out of the body quickly, so that smaller doses throughout the day are most effective, with 250 milligrams being the most the body could utilize at one time.

Dr. Kaufman and his wife took 250 milligrams of niacinamide every three waking hours (six doses) for at least 55 years, believing, as a result of his studies, that it helps prevent many of the physical and mental problems associated with aging, including arthritis, fatigue, muscle strength, loss of balance, depression, and cancer.

Niacinamide has been widely used for a variety of purposes for more than 60 years, and its safety is well known, says Jonathan Wright, M.D. In one of Dr. Kaufman's books, Kaufman described symptoms of niacinamide deficiency:

  • Impaired memory, can't concentrate, easily distracted, slow thought, mental fog.

  • Anxiety for no reason, resistant to making decisions and taking responsibility, lacks initiative, starts projects but never finishes, uncooperative.

  • Quarrelsome, mean, intolerant, opinionated, unreasonable, unhappy, little things annoy, can't take a joke.

Dr. Kaufman found that these symptoms and more went away or improved a lot with the use of niacinamide, says Dr. Wright. Arthritis symptoms also improve or disappear with niacinamide, says Dr. Wright, but it's not a cure; the arthritis symptoms return if patients stop taking it.

Be certain what you're taking is NOT niacin, which can have many more side effects, particularly at high doses. Use niacinamide, not niacin, says Dr. Wright.

Based on Dr. Kaufman's work, Dr. Williams estimates that Alzheimer's patients "would achieve the best results if they took 250 mg every 1½ hours (a total of 12 doses)" for Alzheimers treatment.  For more info on Dr. Wright's regimen, which is higher doses at less frequent intervals, read his newsletter. This larger-dose, less-frequent regimen can cause side effects in a small number of people. Check with your own doctor.

Keep in mind that this Alzheimer's "cure" only works for mice so far. Given the outstanding results in mice, human trials for Alzheimers treatment are proceeding at UC Irvine and in England. In humans, taking 2000 to 3000 milligrams a day is "totally harmless," says Dr. Williams. The toxic dose would be nearly a pound of niacinamide daily, and there has never been a death reported from niacinamide supplementation.

Dr. Williams says, "I personally utilized Dr. Kaufman's protocols for several years and saw some amazing improvements; however, I saw even better responses after switching to a product without preservatives." One source of preservative-free niacinamide for Alzheimers treatment is Freeda Vitamins, 800-777-3737 or

Note: Niacinamide also works for joint function, Mobility and repair, says Dr. Williams. See his article.


Bottom Line Natural Healing with Dr. Mark Stengler, July 2011, by Mark Stengler, NMD

Alternatives newsletter, February 2009, by Dr. David Williams. J Neurosci 08:28:11500-11510

Nutrition & Healing newsletter, March 2009, by Jonathan Wright, M.D.

Life Extension magazine, April 2009, p. 22

Magnesium supplement for Alzheimers treatment

Although magnesium has a long history as a nutrient important for brain function, recent research has confirmed that a special form of it specifically contributes to learning and memory because of its favorable effect on “synaptic plasticity and density.” Synaptic density and plasticity are the structural bases of learning and memory.

A unique supplement, magnesium-L-threonate (MgT), could be an Alzheimers treatment because it rebuilds ruptured synapses and restores degraded neuronal connections seen in Alzheimer’s and other forms of memory loss. Unlike other magnesium supplements, this one significantly raises magnesium levels in the brain. Until the formulation and testing of MgT by scientists at the Massachusetts Institute of Technology (MIT), no widely available kinds of magnesium allowed “rapid absorption and efficient transfer into the central nervous system.”

Tests showed that magnesium-L-threonate improves multiple forms of learning and memory in animals. The tests were done on young and old animals, and the results are so encouraging that human trials are pending.

Following is a list of what researchers discovered during the tests:

  • Novel Object Recognition Test (NORT). This test is about recognizing and identifying new objects. Researchers tested magnesium-L-threonate against magnesium citrate. Only MgT improved both short- and long-term memory, raising scores by 15% for short term memory and 54 percent for long-term memory.
  • Spatial working memory. This type of short-term memory helps us remember where we left things and where we are in relation to the world. It helps you remember locations of items (such as your car keys) or helps you return to the same page you were reading a few minutes ago.

    Without magnesium-L-threonate, both young and old animals forgot about 30% of the time. After 24 days of MgT, both young and aged animals improved by 17 percent. After 30 days of this Alzheimers treatment, older animals performed as well as the younger ones. When MgT supplementation was stopped, younger animals retained the improvement, but older animals declined to where they had started within 12 days. When they started again on MgT, though, their performance climbed back up in 12 days.

  • Enhanced spatial long-term memory. This kind of memory helps us remember where we live or how to get to the grocery store. In this test, researchers used a maze that required test animals to swim and find a submerged platform. Again, both young and old animals did significantly better with magnesium-L-threonate than those who were not taking the supplement.

    After one hour, researchers removed the platform, causing the animals to search for where they had seen it. Both young and old, those with and without MgT, did well, searching for it in the correct quadrant of the water. After 24 hours, the untreated animals, young and old, completely forgot where the platform was and searched randomly in the water.

    Those with the magnesium-L-threonate Alzheimers treatment, however, continued to search in the correct quadrant more than twice as long as they looked in the incorrect areas. They showed improvements in long-term memory of 122% in younger animals and 100% in older animals. “MgT supplementation doubled the accuracy of long-term spatial memory in older animals, and more than doubled it in younger animals.

  • Pattern completion. The ability to have a complete memory based on only partial information is called “pattern completion.” You use this to find your way around a familiar neighborhood after dark or after a heavy snowstorm. Some familiar details are missing, but you can still get around by completing a recognizable pattern.

    As the water-maze test (described above) showed, even when visual cues are removed, animals supplemented with magnesium-L-threonate could find their way around much better than those who had not taken it.

In summary, magnesium-L-threonate as an Alzheimers treatment boosts brain magnesium levels better than standard magnesium supplements, producing dramatic increases in synaptic density and plasticity and similar improvements in memory function itself, giving it potential as an Alzheimer’s treatment.

My summary of this subject was taken from a lengthy article in Life Extension magazine, titled "Novel Magnesium Compound Reverses Neurodegeneration," February 2012, p. 33-36. At the end of the article are 42 scientific references.

Life Extension sells magnesium-L-threonate, and it is readily available online, and probably at your health food store as an Alzheimer's treatment.

Melatonin for Alzheimer's

A study on melatonin for Alzheimers treatment included 80 men and women with mild to moderate Alzheimer's disease. Half the participants got two milligrams of prolonged-release melatonin every night for six months. The others got a placebo. Patients who got the melatonin got significantly highter scores on the IADL and MMSE, meaning better cognitive function and also better sleep efficiency.

IADL measures how well patients can take care of themselves.  MMSE measures memory and cognition.

Here's an easy-to-read version of the study in the Life Extension magazine newsletter, June 9, 2015:

"Melatonin supplementation benefits Alzheimer's disease patients."

Can tocotrienols reverse brain damage?

Al Sears, M.D. has had "great success" in treating patients with Alzheimer's, stroke and dementia with tocotrienols, which are part of the Vitamin E complex. This supplement speeds up brain healing, says Sears, making it appropriate for Alzheimers treatment. Read all about it on the benefits of tocotrienols page.

Turmeric and curcumin for Alzheimers

Turmeric is showing great promise as an Alzheimer's treatment. The active ingredient in turmeric is curcumin. This component is believed to be responsible for most of turmeric’s health effects.

One of the most comprehensive summaries of turmeric studies was published by James A. Duke, Phd., in the October, 2007 issue of Alternative & Complementary Therapies, and summarized in the July, 2008, issue of the American Botanical Council publication HerbClip.

Duke found more than 50 studies on turmeric’s effects in as an Alzheimers treatment. The reports indicate that extracts of turmeric contain a number of natural agents that block the formation of beta-amyloid, the substance responsible for the plaques that slowly obstruct cerebral function in Alzheimer’s disease. Duke concluded turmeric dramatically outperforms many synthetic drugs in its power to both prevent and treat Alzheimer’s plaques.

As for how it works, an important review in Annals of Indian Academy of Neurology, titled "The effect of curcumin (turmeric) on Alzheimer's disease" covers the subject in overwhelming detail.

The review is long and very technical. I have pulled the following out of it for you, hoping to write it in readable English. The quotes portions are directly from the review:

  • Curcumin clears brain plaques found in Alzheimer's patients.

    "The most prominent characteristic feature in AD [Alzheimer's disease] is the presence of beta-amyloid plaques." Curcumin, as an Alzheimers treatment, may help to clear the amyloid plaques found in the brains of Alzheimer's patients.

    "As demonstrated by multiphoton microscopy, curcumin crosses the blood-brain barrier and binds to plaques, thereby reducing the existing senile plaques. "The levels of beta-amyloid in AD mice that were given low doses of curcumin were decreased by around 40% in comparison to those that were not treated with curcumin."
  • Curcumin's anti-inflammatory properties help ease symptoms, and it may play a part in the cure of Alzheimer's disease.

    Curcumin "decreases...oxidation and the free radicals that cause the deterioration of neurons, not only in AD but also in other neuron degenerative disorders such as Huntington's and Parkinson's disease." These antioxidant and anti-inflammatory properties "help ease Alzheimer's symptoms..." Curcumin has a significant effect, and "through its various anti-inflammatory effects, it may have a role in the cure of AD."
  • Curcumin prevents heavy metal toxicity.

    Curcumin, by interaction with heavy metals such as cadmium and lead, prevents neurotoxicity caused by these metals.

Side effects of curcumin

The review says, "No apparent side effects have been reported thus far." However, curcumin interacts with some prescription drugs. Also, it should not be used by people with certain medical conditions. Read the study for details; search on side effect. Be sure to check with your doctor before taking it.

There is much more information available online. Just search on:

Alzheimer's tumeric curcumin

Music and Alzheimer's

Alzheimer's patients remember information better when it is sung to them, rather than spoken. See the study:

Watch an amazing video of a formerly unresponsive man with Alzheimer's/dementia in a nursing home responding to music:

This book looks good. Read the reviews, especially the five-star ones that talk about successfully using the suggestions for Alzheimers treatment in the book. It's expensive, but maybe your library can get it for you.

Is it really Alzheimer's? Checklist

Sometimes, although rarely, symptoms of Alzheimer's are actually caused by something else:

  • Drug reactions
    Drugs can build up in older people, especially those taking several medications and those in poor health generally. In older people, the kidneys and liver don't work as well at detoxifying and eliminating the drugs from the system. The buildup may cause symptoms. Ask your doctor about reducing doses to see if symptoms improve.
  • Vitamin B12 deficiency
    Lack of vitamin B12 can cause dementia symptoms. Eggs, dairy, meat, fish and poultry are good sources of B12, or supplements are readily available.
  • Normal-pressure hydrocephalus
    This condition, which affects a small number of seniors, occurs when too much fluid surrounds the brain. In addition to showing signs of dementia, these people often lose bladder control and walk slowly and hesitantly, as if their feet are stuck to the floor. A surgically-implanted tube to drain the fluid can correct this condition.
  • Subdural hematoma
    Even minor head injuries can cause blood clots in the brain, which can interfere with brain function.
  • Thyroid disease
    Whether the thyroid is underactive or overactive, thyroid disease can cause symptoms the could be mistaken for Alzheimer's.

This information came from the following source: Dear Doctor K, a syndicated newspaper column by Anthony Komaroff, M.D., 2/22/15.


"Come to Me, all of you who are weary and carry heavy burdens, and I will give you rest."  Matthew 11:28.

A number of studies have linked prayer to healing, and although the results have been inconclusive, what could it hurt to talk to the omnipotent creator of the universe? A prayer for healing might go something like this:

"Dear Lord, please hear me now as I pray for your help with (name your problem). I pray you’ll cleanse my body and heal me completely. In Jesus’ name I pray; Amen."

Curious about the Christian religion? What is Christianity?
What is a Christian? What is Christian faith?
To see the answers and find out how to become a Christian,
check out this Web site.

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